Patients who have been mechanically ventilated in intensive care units have long been known to suffer some form of mental impairment as a result. Now, researchers have uncovered a molecular mechanism that may explain why this happens.The study, published in the American Journal of Respiratory and Critical Care Medicine, was conducted by researchers from the University of Oviedo in Spain, St. Michael’s Hospital in Canada, and the Perelman School of Medicine at the University of Pennsylvania.The researchers say that a minimum of 30% of patients in intensive care units (ICU) suffer some form of mental dysfunction, such as anxiety, depression, and most commonly, delirium. They note that the incidence of delirium in patients who are mechanically ventilated is around 80%.They hypothesized that this may be partly a result of damage in the hippocampus, but how ventilation causes this damage has been unclear.Dopamine a cause of apoptosisResearchers have discovered a molecular mechanism that may explain why some patients who are mechanically ventilated in ICUs suffer mental impairments.For their study, the research team analyzed the harvested brains of mice who had been connected to low or high-pressure ventilation for 90 minutes, alongside the brains of control mice who had not been on ventilation.In comparison with the control mice, the mice on ventilation showed evidence of neuronal cell death in the hippocampus as a result of apoptosis – the process of programmed cell death (PCD).
“Memories streamed over her, and she sat up, images converging in her mind’s eye, the sneaker wave of grief catching her in its riptide pull once again, leaving her washed ashore, bereft, with two deep desires: to sleep forever, or to live life for them both. “Oh,”
― Jacqueline Winspear,
I am still not doing very well. I am a mess. Totally a mess. My head is whirling and I am lost. The Internet is slow. I am not used to that. I didn’t get to a meeting and I didn’t get all my stuff out. $100 worth of cleaning is all.
I am still frozen like the Staffy and blank headed. Its cold . I shall have a hot shower and do some thinking.
I am living in a nightmare. A nightmare – alone. Now and then, I come across internet articles and am able to say – ” So that’s what happened. So that’s what’s going on with me”. If I were relying on real life medicos and support , I would truly be alone and lost.
Its evening now and I feel settled. I even feel a tingle of amusement at Life despite still having business to attend to. GET THE LAST BIT OVER AND DONE, LYNNE. Then – gently, gently.
Clarz had earrache today. I went to school with them and minded her in the car while Kaybee ran Saf in. I damned well will adjust to this new life somehows. I think the move has been a good one even though it don’t yet quite fit.
I am on my 4-5 pages of Net tonight and interacting with more people than I can actually handle. O Good Lord. Have mercy upon this Spotted Soul.
Well, there you go – wait a few more minutes and a suckarse day becomes quite pleasant.
“As friends they knew each other’s history, knew the twists and turns that had brought them to this place in the world. And they understood each other’s fears and frailties; nothing had to be explained. Now,”
― Jacqueline Winspear,
One of the things wrong with me is that I seem to have got it ALL WRONG. My entire life. I do not seem to be made of the Stuff that one ought to be made of. That is not an easy discovery and probably simply indicates lack of Meetings. Nonetheless, I am single, sick and poor with no security.
I THOUGHT IT WOULD BE DIFFERENT.
ST. HELENA — Glancing into the rearview mirror, Peggy O’Kelly, owner of the St. Helena Olive Oil Co., saw a car behind her but thought little of it. The traffic ahead had stopped on Highway 29, a normal event. O’Kelly had noticed it and slowed to stop, but the driver behind her didn’t. When the vehicle crashed into hers, it was traveling at 45 mph, totaling her car and upending her life.When she awoke in the hospital doctors told her the external scratches and bruises would heal, but what they diagnosed as a minor concussion at the time still remains as a haunting reminder of the traumatic event.“After the accident doctors told me that I’d be fine with rest,” she said. “So I went home. I was busy with my business and was in the middle of negotiating a deal with investors to expand. But within a few days I knew something was really wrong. I just couldn’t think straight and I often felt emotional and unable to focus. Then one day I was driving with my daughters, and they said, ‘Mom, there’s something wrong with you, you’re not making any sense.’ That’s when I told myself, ‘I don’t care what these doctors are saying, there is something really, really wrong with me.’”After repeated visits, however, O’Kelly’s doctors assured her that the effects of the concussion would not last much longer and that she’d soon be back to normal. She waited and tried to carry on.Yet within a few months of the accident O’Kelly’s entire life had changed: She was forced to relinquish her downtown store in St. Helena and part with her longtime employees, and she was unable to complete her plans to expand the business, forgoing what had been a nearly completed investment deal. Bright light and even a few minutes of concentration had the potential to result in migraine-type headaches and intense fatigue. She remained undiagnosed and concerned.“With a brain injury it’s not like a broken bone,” said O’Kelly. “There’s no outward sign of the condition and so people just see you and think, ‘Well, you look fine, so things are OK.’ But they’re not. Not at all.”
ON OCTOBER 12, 2016, 1:05PM 2 COMMENTSFACEBOOKTWITTERTUMBLRREDDITLeonard Cohen has seen a lot of life and made a lot of music, but the 82-year-old singer-songwriter sounds like he’s finally coming to terms with the fact that it may all be over soon. In a recent profile by The New Yorker’s David Remnick, Cohen confirms that his touring days may be coming to a close and that he’s now more or less “confined to barracks” on account of his health. As Remnick notes, it’s highly likely that the weather-beaten road warrior who toured continuously between 2008 and 2013 may never grace a stage again.Cohen’s fatalistic tone in the article may be the result of losing his former love and muse, Marianne Ihlen, to cancer over the summer. He suspects his own clock is ticking, too, and sounds dubious about the prospect of completing another album after his forthcoming You Want It Darker, which arrives on October 21st via Sony.“I don’t think I’ll be able to finish those songs,” he reflects. “Maybe, who knows? And maybe I’ll get a second wind, I don’t know. But I don’t dare attach myself to a spiritual strategy. I don’t dare do that. I’ve got some work to do. Take care of business. I am ready to die. I hope it’s not too uncomfortable. That’s about it for me.”